Which mechanism leads to the necrosis of bones in osteomyelitis?

The mechanism that leads to the necrosis of bones in osteomyelitis is devascularization. Osteomyelitis is an infection of the bone that typically arises from bacteria entering the bone tissue, often via the bloodstream or following a traumatic injury. The infection causes inflammation, which can significantly affect the blood supply to the affected bone.

When blood flow is compromised due to inflammation or infection, the bone tissue receives inadequate oxygen and nutrients. This lack of adequate blood supply leads to devascularization, meaning that the bone tissue fails to survive and becomes necrotic. Necrosis refers to the death of tissue, which in the context of osteomyelitis, can lead to the deterioration of the bone structure and function.

Other mechanisms, such as injury or overuse, do not directly lead to necrosis as a primary factor in the context of osteomyelitis. Similarly, while dehydration can affect tissue health, it is not the primary cause of bone necrosis in this particular condition. Thus, devascularization stands out as the critical mechanism causing necrosis in osteomyelitis.